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ESPRIT Women's Trouser
ESPRIT Women's Trouser
At the beginning the vision of a positive attitude to life: Esprit was founded in 1968 in California by the married couple Susie and Doug Tompkins. Inspired by the revolutionary spirit of the 60s, the brand developed a clear philosophy – to celebrate authentic people and true community, in the sense of the brand promise: "Feel good, look good".
The company's "Esprit de Corps" is characterised by a positive and appreciative attitude towards life, which play an important role in community, family and friends – in the casual-cool Californian style. The Esprit style. ESPRIT is present in over 40 countries and distributes its products internationally in around 580 own retail stores as well as over 5,400 wholesale locations, including franchise stores and retail premises in warehouses. The group markets its products under the two brands Esprit and edc by ESPRIT. Esprit has been listed on the Hong Kong stock exchange since 1993 and has centres in Germany and Hong Kong. "br""br"Sustainability: "br""br"Esprit understands sustainable materials of high-quality materials and produced in a environmentally friendly production process as possible. Esprit ensures that materials can be recycled or composted. "br""br"Esprit always strives for the highest quality in the manufacture of its products, so that they stay in good and portable condition for as long as possible. For this reason, we train our designers on the subject of circulation economy and work on a process to ensure that all our garments are well constructed, made with durable materials and, where possible, timeless and flexible in terms of their application.
Gut is a leading international journal in gastroenterology and hepatology and has an established reputation for publishing first class clinical research of the alimentary tract, the liver, biliary tree and pancreas. Gut delivers up-to-date, authoritative, clinically oriented coverage in all areas of gastroenterology and hepatology. Regular features include articles by leading authorities describing novel mechanisms of disease and new management strategies, both diagnostic and therapeutic, likely to impact on clinical practice within the foreseeable future.
Our new online collection highlights all research relating to the COVID-19 pandemic published by Gut, Frontline Gastroenterology and BMJ Open Gastroenterology. It is updated regularly as new articles are published.
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Spatial profiling of gastric cancer metastases reveals principles of tumour dissemination
To cite: Sundar R, Liu DH, Hutchins GG, et al. Gut 2021;70:1823-1832.
Read the full article here: link
Objective: Endoscopic mucosal biopsies of primary gastric cancers (GCs) are used to guide diagnosis, biomarker testing and treatment. Spatial intratumoural heterogeneity (ITH) may influence biopsy-derived information. We aimed to study ITH of primary GCs and matched lymph node metastasis.
Conclusions: In GC, regional lymph node metastases are likely to originate from deeper subregions of the primary tumour. Future clinical trials of novel targeted therapies must consider assessment of deeper subregions of the primary tumour and/or metastases as several therapeutically relevant genes are only mutated, overexpressed or amplified in these regions.