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La Blanca Women's Island Goddess Underwire Surplice Mio One Piec

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a leading international journal from BMJ and BSG, publishes cutting-edge gastroenterology and hepatology research

Impact Factor: 23.059
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Gut is a Plan S compliant Transformative Journal.

Gut is a leading international journal in gastroenterology and hepatology and has an established reputation for publishing first class clinical research of the alimentary tract, the liver, biliary tree and pancreas. Gut delivers up-to-date, authoritative, clinically oriented coverage in all areas of gastroenterology and hepatology. Regular features include articles by leading authorities describing novel mechanisms of disease and new management strategies, both diagnostic and therapeutic, likely to impact on clinical practice within the foreseeable future.

Gut is an official journal of the British Society of Gastroenterology and has two companion titles, Frontline Gastroenterology for education and practice and BMJ Open Gastroenterology for sound science clinical research.

Editor-in-Chief: Professor Emad El-Omar, University of New South Wales, Sydney, Australia
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Our new online collection highlights all research relating to the COVID-19 pandemic published by Gut, Frontline Gastroenterology and BMJ Open Gastroenterology. It is updated regularly as new articles are published.

 

All content is free to read and features original research, commentaries, letters and editorials from all three journals published with the British Society of Gastroenterology (BSG)

 

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Spatial profiling of gastric cancer metastases reveals principles of tumour dissemination

To cite: Sundar R, Liu DH, Hutchins GG, et al. Gut 2021;70:1823-1832.

Read the full article here: link
Objective: Endoscopic mucosal biopsies of primary gastric cancers (GCs) are used to guide diagnosis, biomarker testing and treatment. Spatial intratumoural heterogeneity (ITH) may influence biopsy-derived information. We aimed to study ITH of primary GCs and matched lymph node metastasis.

Conclusions: In GC, regional lymph node metastases are likely to originate from deeper subregions of the primary tumour. Future clinical trials of novel targeted therapies must consider assessment of deeper subregions of the primary tumour and/or metastases as several therapeutically relevant genes are only mutated, overexpressed or amplified in these regions.

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